Yangambin 是一种呋喃木脂素 (furofuran lignan)，已经从诸如番荔枝科 (Annonaceae family) 的植物中分离出来，包括：R. pickeli，R. exalbida 和 R. mucosa 以及 Magnolia biondii。 Yangambin 是一种选择性 PAF 受体拮抗剂，通过调控 Ca2+ 通道抑制 Ca2+ 流入，导致 [Ca2+]i 在血管平滑肌细胞和随后的外周血管舒张中减少。Yangambin 表现出对 β-氨基己糖苷酶 (β-hexosaminidase) 的抗过敏活性，IC50 为 33.8 μM，抗炎活性的 IC50 为 37.4 μM。
| 生物活性 |
Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca influx through voltage-gated Ca channels, leading to the reduction in [Ca]i in vascular smooth muscle cells and consequent peripheral vasodilation. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC50 of 33.8 μM and for anti-inflammatory activity with an IC50 of 37.4 μM. |
|---|---|
| 分子式 |
C24H30O8
|
| 分子量 |
446.49
|
| CAS号 |
13060-14-5
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
纯度： 98%
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