Nepodin - CAS:3785-24-8

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Nepodin (Synonyms:Musizin)

目录号 : KM17987 CAS No. : 3785-24-8 纯度 : 98%

Data Sheet 产品使用指南

Nepodin (Musizin) 是一种醌氧化还原酶 (PfNDH2) 抑制剂，从 Rumex crispus 中分离。Nepodin (Musizin) 通过激活 AMPK 刺激 GLUT4 向质膜的转运。Nepodin (Musizin) 具有抗糖尿病和抗疟疾的作用。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus.Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK.Nepodin (Musizin) has antidiabetic and antimalarial activities.

体外研究

Nepodin (Musizin) exhibits significant IC₅₀ values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively.

体内研究

Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner.

Animal Model:	C57BL/KsJ-db/db mice
Dosage:	2 mg/kg; 10 mg/kg
Administration:	Orally administration; 2-10 mg/kg; 4 weeks
Result:	Had antihyperglycemic potential and improved insulin resistance.

分子式

C₁₃H₁₂O₃

分子量

216.23

CAS号

3785-24-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 125 mg/mL (578.09 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.6247 mL	23.1235 mL	46.2471 mL
5 mM	0.9249 mL	4.6247 mL	9.2494 mL
10 mM	0.4625 mL	2.3124 mL	4.6247 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%