Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus.Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK.Nepodin (Musizin) has antidiabetic and antimalarial activities.
体外研究
Nepodin (Musizin) exhibits significant IC50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively.
体内研究
Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner.
Animal Model:
C57BL/KsJ-db/db mice
Dosage:
2 mg/kg; 10 mg/kg
Administration:
Orally administration; 2-10 mg/kg; 4 weeks
Result:
Had antihyperglycemic potential and improved insulin resistance.
分子式
C13H12O3
分子量
216.23
CAS号
3785-24-8
运输条件
Room temperature in continental US; may vary elsewhere.