Galanthamine hydrobromide - CAS:1953-04-4

您当前的位置：

Galanthamine hydrobromide (Synonyms:氢溴酸加兰他敏; Galantamine hydrobromide)

目录号 : KM17944 CAS No. : 1953-04-4 纯度 : ≥98%

Data Sheet 产品使用指南

Galanthamine hydrobromide (Galantamine hydrobromide) 是一种选择性、可逆、竞争性的生物碱 AChE 抑制剂，其 IC₅₀ 值为 0.35 µM。Galanthamine hydrobromide 是有效的人 nAChRs α₃β₄、α₄β₂、α₆β₄ 变构增强配体。Galanthamine hydrobromide 被开发用于阿尔茨海默症的研究。

规格	价格	是否有货
50mg		In-stock
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

Ginkgolide J In-stock
Ginkgolide K In-stock
THK-5470 In-stock
NH-3 In-stock
Velufenacin In-stock

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC₅₀ of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α₃β₄, α₄β₂, α₆β₄ nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD).

体外研究

Galanthamine hydrobromide is 53-fold selectivity for AChE over butyrylcholinesterase.
Galanthamine hydrobromide (25-1000 µM) inhibits both Aβ 1-40 (50 µM) and Aβ 1-42 (50 µM) aggregation.
Galanthamine hydrobromide (25-1000 µM) protects against Aβ(1-40) and Aβ(1-42) toxicity in SH-SY5Y cells.
Galanthamine hydrobromide also dramatically reduces Aβ(1-40)-induced cellular apoptosis.

体内研究

Galanthamine hydrobromide (1.25-2.5 mg/kg; i.p. ) reduces cognitive deficits in APP23 mice.
Galanthamine hydrobromide (10 mg/kg; i.g.) displays short elimination half-life of approximately 2 h in wild-type mice.

Animal Model:	APP23 mice
Dosage:	1.25 mg/kg, 2.5 mg/kg
Administration:	Intraperitoneal injection, daily, 1 week
Result:	Effectively remedied the spatial learning deficit.

Animal Model:	Female 57B1/6J wild type
Dosage:	10 mg/kg
Administration:	Oral gavage (Pharmacokinetic Analysis)
Result:	C_max (0.31 µg/mL), t_1/2β (1.6 h), AUC_0-24h (0.67 µg • h/mL).

分子式

C₁₇H₂₁NO₃^.HBr

分子量

368.3

CAS号

1953-04-4

中文名称

氢溴酸加兰他敏；氢溴酸加兰它敏；氢溴酸加兰他敏

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 25 mg/mL (67.88 mM; Need ultrasonic)

DMSO : ≥ 3.7 mg/mL (10.05 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7154 mL	13.5770 mL	27.1540 mL
5 mM	0.5431 mL	2.7154 mL	5.4308 mL
10 mM	0.2715 mL	1.3577 mL	2.7154 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

临床试验

科研文献

纯度： ≥98%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 3 篇科研文献

The molarity calculator equation

The dilution calculator equation