Malantide 是一种合成的十二肽，由被磷酸化酶激酶β亚基上的 PKA 磷酸化的位点衍生而来。Malantide 是 PKA 的高度特异性底物，Km 为 15 μM，并且在各种大鼠组织提取物中显示出 PKI 抑制 > 90％底物磷酸化。Malantide 也是 PKC 的有效底物，Km 为 16 μM。
| 生物活性 |
Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts. Malantide is also an efficient substrate for PKC with a Km of 16 μM. |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 体外研究 |
The Km values of Malantide are 15 μM and 223 μM for PKA and PKG, respectively. The Vmax values are 23.8 units/mg and 6.6 units/mg for for PKA and PKG, respectively. |
||||||||||||
| 分子式 |
C72H124N22O21
|
||||||||||||
| 分子量 |
1633.89
|
||||||||||||
| CAS号 |
86555-35-3
|
||||||||||||
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||
| 储存方式 |
|
纯度： 98%
关注我们
获得KKL MED 最新资讯
咨询热线：
400-881-9290
Data Sheet