K-252c，一种十字孢碱的类似物，可从Nocardiopsis sp.中分离得到，是一种能透过细胞的、PKC 的抑制剂，IC50 值为2.45 µM。K-252c可诱导人慢性粒细胞白血病癌细胞凋亡。K-252c还能抑制β内酰胺酶、胰凝乳蛋白酶和苹果酸脱氢酶。
| 生物活性 |
K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase. |
|---|---|
| 分子式 |
C20H13N3O
|
| 分子量 |
311.34
|
| CAS号 |
85753-43-1
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
纯度： 98%
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