Metformin hydrochloride - CAS:1115-70-4

规格	价格	是否有货
10mg		In-stock
25mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

规格

价格

是否有货

数量

10mg

In-stock

25mg

In-stock

50mg

询价

In-stock

100mg

询价

In-stock

Other Forms of Rapamycin:

生物活性

Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin hydrochloride triggers autophagy.

体外研究

Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) inhibits proliferation of ESCs in a concentration-dependent manner. The IC₅₀ is 2.45 mM for A-ESCs and 7.87 mM for N-ESCs. Metformin shows pronounced effects on activation of AMPK signaling in A-ESCs from secretory phase than in cells from proliferative phase.
Metformin hydrochloride (0-500 μM) decreases glycogen synthesis in a dose-dependent manner with an IC₅₀ value of 196.5 μM in cultured rat hepatocytes.
Metformin hydrochloride shows cell viability and cytotoxic effects on PC-3 cells with IC₅₀ of 5 mM.

体内研究

Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride; 100 mg/kg, p.o.) alone, and metformin (25, 50, 100 mg/kg) with NSC 37745 groups attenuates myocyte necrosis through histopathological analysis.

分子式

C₄H₁₁N₅

分子量

165.62

CAS号

1115-70-4

中文名称

盐酸二甲双胍；甲福明；降糖片

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 250 mg/mL (1509.48 mM; Need ultrasonic)

DMSO : ≥ 1.7 mg/mL (10.26 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	6.0379 mL	30.1896 mL	60.3792 mL
5 mM	1.2076 mL	6.0379 mL	12.0758 mL
10 mM	0.6038 mL	3.0190 mL	6.0379 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (603.79 mM); Clear solution; Need ultrasonic
2.

请依序添加每种溶剂： 5% DMSO 40% PEG300 5% Tween-80 50% saline
Solubility: ≥ 3 mg/mL (18.11 mM); Clear solution
3.

请依序添加每种溶剂： 5% DMSO 95% (20% SBE-β-CD in saline)
Solubility: ≥ 3 mg/mL (18.11 mM); Clear solution

临床试验

科研文献

纯度： 98%

Data Sheet

产品使用指南

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 51 篇科研文献

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