Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties.
体外研究
Pinocembrin (5, 10, 25, 50, 100 or 200 µM, 24 hours) significantly reduces cell viability of RBL-2H3 cells.
Pinocembrin (25 or 50 µM) suppresses iNOS, PGE-2 and COX-2 levels, increases p38-Mapk and IкB-α, and inhibits phosphorylation of IкB-α.
Cell Viability Assay
Cell Line:
RBL-2H3 cells
Concentration:
5, 10, 25, 50, 100 or 200 µM
Incubation Time:
24 hours
Result:
Decreased cell viability by ∼50% at ≥ 100 µM. Showed 75% cell viability at lower concentrations.
分子式
C15H12O4
分子量
256.25
CAS号
480-39-7
中文名称
松属素;乔松素
运输条件
Room temperature in continental US; may vary elsewhere.