α-MSH (alpha-melanocyte-stimulating hormone) TFA 作为内源性神经肽，是一种内源性 melanocortin receptor 4 (MC4R) 激动剂，具有抗炎、解热作用。α-MSH TFA 是前阿皮黑素皮质激素 (POMC) 的翻译后衍生物。
| 生物活性 |
α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH TFA is a post-translational derivative of pro-opiomelanocortin (POMC). |
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| 体外研究 |
α-MSH TFA modulates CNS inflammation by acting directly on melanocortin receptors in glial cells. α-MSH TFA modulates NFκB activation. α-MSH TFA inhibits translocation of transcription factor κB to the nucleus. |
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| 体内研究 |
α-MSH TFA (50 µg/0.2 ml saline; i.p.) given systemically effectively modulates inflammatory reactions.
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| 分子式 |
C79H110F3N21O21S
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| CAS号 |
171869-93-5
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 溶解性数据 |
In Vitro:
H2O : 25 mg/mL (Need ultrasonic) |
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| 科研文献 |
纯度： 98%
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