Microcystin-LR 是蛋白磷酸酶 1 型和 2A 型 (PP1/2A) 的有效抑制剂，其 IC50 值分别为 1.7 nM，0.04 nM。
| 生物活性 |
Microcystin-LR is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC50s of 1.7 nM and 0.04 nM, respectively. |
|---|---|
| 体外研究 |
Microcystins are toxic molecules produced by cyanobacterial blooms due to water eutrophication. Microcystin-LR proves to be a potent inhibitor of type 1 (IC50=1.7 nM) and type 2A (IC50= 0.04 nM) protein phosphatases. Microcystin-LR inhibits the activity of both type 1 and type 2A phosphatases >10-fold more potently than okadaic acid under the same conditions. Type 2A protein phosphatases in dilute mammalian cell extracts are found to be completely inhibited by 0.5 nM microcystin-LR while type 1 protein phosphatases are only slightly affected at this concentration. |
| 分子式 |
C49H74N10O12
|
| 分子量 |
995.17
|
| CAS号 |
101043-37-2
|
| 中文名称 |
微囊藻毒素-LR
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 溶解性数据 |
In Vitro:
Ethanol : 0.5 mg/mL (0.50 mM; Need ultrasonic) |
| 科研文献 |
纯度： ≥95%
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