WKYMVM-NH2 TFA - CAS:1435781-74-0

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WKYMVM-NH2 TFA

目录号 : KM14179 CAS No. : 1435781-74-0 纯度 : 98%

Data Sheet 产品使用指南

WKYMVM-NH2 TFA 是有效的 N-甲酰肽受体 FPR1 和 FPRL1/2 的激动剂，同时可以激活一些白细胞效应功能，如趋化性、激活补体受体-3 及 NADPH 氧化酶。

规格	价格	是否有货
1mg		In-stock
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase.

体外研究

WKYMVM-NH2 TFA (10-1000 nM; 24 hours) induces Caco-2 cells proliferation.

Cell Proliferation Assay

Cell Line:	Caco-2 cells (the intestinal epithelial cells)
Concentration:	0 nM, 10 nM, 100 nM, 1000 nM
Incubation Time:	24 hours
Result:	Induced cell proliferation.

体内研究

WKYMVM-NH2 TFA (8 mg/kg; six times; for 5 days) ameliorates DSS-induced ulcerative colitis.
WKYMVM-NH2 TFA affects cytokine (IL-17, IFN-γ, IL-6, IL-1β and TNF-α) profiles in the DSS colitis model.

Animal Model:	Six-week-old C57BL/6 mice, DSS model
Dosage:	8 mg/kg
Administration:	Subcutaneously injected, six subcutaneous administrations at 12-h intervals, for 5 days
Result:	Attenuated the DSS-induced increase in the bleeding score and the stool score.

分子量

970.13

CAS号

1435781-74-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 12.5 mg/mL (12.88 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.0308 mL	5.1539 mL	10.3079 mL
5 mM	0.2062 mL	1.0308 mL	2.0616 mL
10 mM	0.1031 mL	0.5154 mL	1.0308 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%

Data Sheet

产品使用指南

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Other Forms of Rapamycin:

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