Direct Violet 1, an azo dye, is a textile dye. Direct Violet 1 is also the protein-protein interaction (PPI) between the SARS-CoV-2 spike protein and ACE2 inhibitor with IC50s of 1.47-2.63 µM.
体外研究
Direct Violet 1 inhibits SARS-CoV-2-S-RBD binding to human ACE2, inhibits SARS-CoV-S1S2 binding to ACE2, and inhibits TNF-R1 binding to TNFα with IC50 values of 1.47 µM, 2.63 µM, and 2.11 µM, respectively.
Direct Violet 1 inhibits SARS-CoV-2 pseudovirus entry into hACE2 expressing host cells in a concentration-dependent manner with an IC50 of 35.8 µM.
分子式
C32H22N6O8S2-2.2[Na+]
分子量
728.66
CAS号
2586-60-9
中文名称
直接青莲N;直接紫1;直接紫N
运输条件
Room temperature in continental US; may vary elsewhere.