Cycloleucine - CAS:52-52-8

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Cycloleucine (Synonyms:环亮氨酸)

目录号 : KM13673 CAS No. : 52-52-8 纯度 : ≥98%

Data Sheet 产品使用指南

Cycloleucine 是一种 S-腺苷甲硫氨酸介导的甲基化的特异性抑制剂。Cycloleucine 是 NMDA 受体甘氨酸变构位点的拮抗剂，K_i 值为 600 μM。Cycloleucine 在体外也是 ATP：L-蛋氨酸-S-腺苷基转移酶的竞争性抑制剂。Cycloleucine 具有抗焦虑和抑制细胞作用。

规格	价格	是否有货
25mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a K_i of 600 μM. Cycloleucine is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine has anxiolytic and cytostatic effects.

体外研究

Cycloleucine (4-40 mM; 3 h) blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts.
Cycloleucine (40 mM; 24 h) blocks the formation of both mA and the penultimate G in B77 38S RNA subunits by greater than 90%.
Cytostatic (10 µg/mL) inhibits the viability human KB and mouse L1210s leukemia cell lines.

体内研究

Cycloleucine (0.5-4 µg; intracerebroventrical injection) increases time spent in open arms, open arm entries, and extreme arrivals in rats. Cycloleucine reduces thymus and spleen weights in Semliki Forest virus (SFV) strain A7(74) infected and control mice.

Animal Model:	Male rats bilaterally cannulated into the nucleus accumbens septi (NAS)
Dosage:	1 µL of 0.5, 1.0, 2.0, 4 µg/µL
Administration:	Intracerebroventrical injection
Result:	Increased time spent in the open arms and extreme arrivals at all doses. Increased open arm entries at the dose of 4 μg.

分子式

C₆H₁₁NO₂

分子量

129.16

CAS号

52-52-8

中文名称

环亮氨酸；1氨基环戊烷甲酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 50 mg/mL (387.12 mM; Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	7.7423 mL	38.7117 mL	77.4233 mL
5 mM	1.5485 mL	7.7423 mL	15.4847 mL
10 mM	0.7742 mL	3.8712 mL	7.7423 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%

Data Sheet

产品使用指南

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Other Forms of Rapamycin:

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