Proflavine hemisulfate - CAS:1811-28-5

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Proflavine hemisulfate (Synonyms:Proflavin hemisulfate; 3,6-Diaminoacridine hemisulfate)

目录号 : KM13379 CAS No. : 1811-28-5 纯度 : 98%

Data Sheet 产品使用指南

Proflavine hemisulfate 是一种吖啶染料，也是一种 DNA嵌入剂。可用作抗菌剂 (Anti-microbial)。Proflavine hemisulfate 可作为 K_ir3.2 孔阻滞剂。Proflavine hemisulfate 可用于研究与 K_ir3.2 相关的神经系统疾病。

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100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

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生物活性

Proflavine hemisulfate, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent. Proflavine hemisulfate behaves as a pore blocker for K_ir3.2. Proflavine hemisulfate is a potential lead compound for K_ir3.2-associated neurological diseases.

体外研究

Proflavine (0.1-10 μM; 24 hours) inhibits the growth of K_ir3.2-transformant cells and K_ir3.2 activity in a concentration-dependent manner.
Proflavine (300 μM) progressively reduces the current amplitude of K_ir3.2 mutant to 27.7±4.3% of the control.

Cell Viability Assay

Cell Line:	K_ir3.2-transformant BYT123 cells
Concentration:	0.1, 1, and 10 μM
Incubation Time:	24 hours
Result:	Dose-dependent inhibition of the growth of K_ir3.2-transformant cells. Attenuated the growth of K_ir3.2-transformant cells without affecting the growth of control cells.

体内研究

The concentrations of Proflavine (20 mg/kg) in whole blood after intravenous injection decreased rapidly at the beginning and remained stable from around 30 min after dosing.

Animal Model:	Adult male Sprague Dawley rats (weighing approximately 200 g)
Dosage:	20 mg/kg (Pharmacokinetic Analysis)
Administration:	Intravenous injection; 2, 4, 5, 10, 15, 20, 25, and 30 min after dosing
Result:	Concentration decreased rapidly from whole blood in the first 5 min after dosing, followed by a slower decrease.

分子式

C₁₃H₁₃N₃O₄S

分子量

307.32

CAS号

1811-28-5

中文名称

硫酸原黄素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 16.67 mg/mL (64.54 mM; ultrasonic and warming and heat to 60°C)

H₂O : ≥ 5 mg/mL (19.36 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.8716 mL	19.3581 mL	38.7162 mL
5 mM	0.7743 mL	3.8716 mL	7.7432 mL
10 mM	0.3872 mL	1.9358 mL	3.8716 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

临床试验

纯度： 98%

Data Sheet

产品使用指南

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