Urapidil HCl is an α1-adrenoceptor antagonist and 5-HT1A receptor agonist.
Target: α1-adrenoceptor; 5-HT1A receptor
Urapidil hydrochloride is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. Urapidil has an alpha-blocking effect but, unlike other alpha-blockers, also has a central sympatholytic effect mediated via stimulation of serotonin 5HT1A receptors in the central nervous system [1]. Urapidil has an alpha-blocking effect but, unlike other alpha-blockers, also has a central sympatholytic effect mediated via stimulation of serotonin 5HT1A receptors in the central nervous system. Several studies have suggested that oral urapidil is effective and well tolerated when used as second-line therapy in patients with BP inadequately controlled with other agents. Urapidil has also been shown to improve glucose and lipid metabolism in hypertensive patients with concomitant diabetes and/or hyperlipidemia [2].
IC50&Target
5-HT1A Receptor
分子式
C20H30ClN5O3
分子量
423.94
CAS号
64887-14-5
中文名称
盐酸乌拉地尔
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
溶解性数据
In Vitro:
H2O : 100 mg/mL (235.88 mM; Need ultrasonic)
DMSO : 14.29 mg/mL (33.71 mM; ultrasonic and warming and heat to 60°C)