UNC2881 is a potent and specific Mer kinase inhibitor; inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM.
IC50 value: 22 nM [1]
Target: Mer kinase inhibitor
Treatment with UNC2281 is also sufficient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular domain of EGFR. In addition, UNC2881 potently inhibits collagen-induced platelet aggregation, suggesting that this class of inhibitors may have utility for prevention and/or treatment of pathologic thrombosis.
分子式
C25H33N7O2
分子量
463.58
CAS号
1493764-08-1
运输条件
Room temperature in continental US; may vary elsewhere.