CCT007093 - CAS:176957-55-4

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CCT007093

目录号 : KM11229 CAS No. : 176957-55-4 纯度 : ≥98%

Data Sheet 产品使用指南

CCT007093 是有效的蛋白磷酸酶 1D (PPM1D Wip1) 的抑制剂。Wip1 的抑制可激活mTORC1 通路，增强肝切除手术后肝细胞的增殖。

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50mg		In-stock
100mg		In-stock
500mg		In-stock
1g	询价	In-stock
5g	询价	In-stock

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生物活性

CCT007093 is an effective protein phosphatase 1D (PPM1D Wip1) inhibitor. Wip1 inhibition can activate the mTORC1 pathway and enhance hepatocyte proliferation after hepatectomy.

体外研究

CCT007093 (25 or 50 µM, 8 h) significantly increases the phosphorylation levels of mTOR at Ser2448, Ser2481 and Ser2159, and the phosphorylation levels of p70S6K (Thr389) and S6 (Ser235/236) are also up-regulated in transfected HEK293T cell line.
CCT007093 shows specificity for MCF-7 cells, reducing viability by 40% after 2 days with no observable effect on the growth of HeLa cells.
CCT007093 induces P38 phosphorylation at 4 h post exposure in MCF-7 cells (sensitive to PPM1D inhibition), and does not induce P38 phosphorylation in HeLa cells (relatively resistant to PPM1D inhibition).

Western Blot Analysis

Cell Line:	HEK293T cell line.
Concentration:	25 or 50 µM.
Incubation Time:	8 h.
Result:	The phosphorylation levels of mTOR at Ser2448, Ser2481 and Ser2159 were all significantly increased. The phosphorylation levels of p70S6K (Thr389) and S6 (Ser235/236) were also up-regulated.

体内研究

CCT007093 (6.4 mg/kg) enhances liver regeneration and increases the survival rate of mice following major hepatectomy.

Animal Model:	Wild-type mice.
Dosage:	3.2 and 6.4 mg/kg.
Administration:	Injected intraperitoneally 4 times (mice were sacrificed at 36 h post-PH).
Result:	Significantly improved survival in mice following major hepatectomy (80% hepatectomy). The level of PCNA was also significantly increased in the liver of CCT007093-treated mice at 36h, 48h and 72h post-PH.

分子式

C₁₅H₁₂Os₂

分子量

272.39

CAS号

176957-55-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMF : 3.33 mg/mL (12.23 mM; Need ultrasonic)

DMSO : ≥ 2.8 mg/mL (10.28 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.6712 mL	18.3560 mL	36.7121 mL
5 mM	0.7342 mL	3.6712 mL	7.3424 mL
10 mM	0.3671 mL	1.8356 mL	3.6712 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

科研文献

•J Inflamm Res. 2021 Dec 14;14:6857-6869.

纯度： ≥98%

Data Sheet

产品使用指南

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