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PTPN22-IN-1 is a potent PTPN22 inhibitor (IC₅₀=1.4 µM; K_i=0.50 µM). PTPN22-IN-1 exhibits >7-10 fold selectivity for PTPN22 over similar phosphatases. PTPN22-IN-1 augments antitumor immune responses. From WO2021007491A1 compound L-1.

PTPN22-IN-1 (Compound L-1) (WT mice; intraperitoneally) significantly reduces MC38 tumor growth. PTPN22-IN-1 (syngeneic immunocompetent model; CT26 in Balb/c mice) shows similar antitumor effects.
Administration of L-l intraperitoneally at 10 mg/kg yielded an average AUC of 4.55 µM h and C_max of 1.1 1 µM (Fig. 9d), which is more than twice of its K_i value.

PTPN22-IN-1 (Compound L-1) (WT mice; intraperitoneally) significantly reduces MC38 tumor growth. PTPN22-IN-1 (syngeneic immunocompetent model; CT26 in Balb/c mice) shows similar antitumor effects.
Administration of L-l intraperitoneally at 10 mg/kg yielded an average AUC of 4.55 µM h and C_max of 1.1 1 µM (Fig. 9d), which is more than twice of its K_i value.

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