Etilevodopa hydrochloride - CAS:39740-30-2

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Etilevodopa hydrochloride (Synonyms:L-DOPA ethyl ester hydrochloride; Levodopa ethyl ester hydrochloride)

目录号 : KM10402 CAS No. : 39740-30-2 纯度 : 98%

Data Sheet 产品使用指南

Etilevodopa hydrochloride (L-Dopa ethyl ester hydrochloride) 是 Levodopa 的前药，在胃肠道中被非特异性酯酶快速水解为 Levodopa 和乙醇。Etilevodopa 用于帕金森病 (PD)的相关研究。Levodopa 是多巴胺的直接前体，有助于中枢神经系统的渗透和传递多巴胺。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester prodrug of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable prodrug as it facilitates CNS penetration and delivers dopamine.

体外研究

Etilevodopa (L-Dopa ethyl ester) hydrochloride passes unchanged through the stomach to the duodenum, where it is rapidly hydrolyzed by local esterases to Levodopa and ethanol, and is subsequently absorbed into the blood stream as Levodopa.
Compared with standard Levodopa, Etilevodopa hydrochloride has greater solubility in the stomach, faster passage to the small intestine, and a shortened time to maximum Levodopa concentration.

分子式

C₁₁H₁₆ClNO₄

分子量

261.70

CAS号

39740-30-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据

In Vitro:

H₂O : 125 mg/mL (477.65 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.8212 mL	19.1058 mL	38.2117 mL
5 mM	0.7642 mL	3.8212 mL	7.6423 mL
10 mM	0.3821 mL	1.9106 mL	3.8212 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%