TMCB 是一种选择性、ATP 竞争性的酪蛋白激酶 II CK2 抑制剂，对于两种不同的催化 CK2 亚基 α 和 α' 的 Ki 值分别为 83 和 21 nM.
| 生物活性 |
TMCB is a selective, ATP-competitive CK2 (casein kinase II) inhibitor with distinct Ki values of 83 nM and 21 nM for the two different catalytic CK2 subunits α and α', respectively. |
|---|---|
| 体外研究 |
The inhibition of TMCB toward the purified CK2 holoenzyme CK2α2β2 results in a Ki value of 10.1 nM. In addition, Ki values are determined with the surface displayed isoform CK2 holoenzymes and turned out to be of 31.1 nM for CK2α2β2 and 19.6 nM for CK2α'2β2. The surface display of CKα and CK2α', in the context of the corresponding holoenzymes, can be used to identify selective compounds. |
| 分子式 |
C11H9N3O2Br4
|
| 分子量 |
534.82
|
| CAS号 |
905105-89-7
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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