RRD-251 - CAS:72214-67-6

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RRD-251

目录号 : KM10185 CAS No. : 72214-67-6 纯度 : 98%

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RRD-251 是一种视网膜母细胞瘤肿瘤抑制蛋白 (Rb)-Raf-1相互作用 (Rb-Raf-1 interaction) 的抑制剂，具有高效的抗增殖、抗血管生成和抗肿瘤活性。

规格	价格	是否有货	数量
5mg		In-stock

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Ginkgolic Acid In-stock
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生物活性

RRD-251 is an inhibitor of retinoblastoma tumor suppressor protein (Rb)-Raf-1 interaction, with potent anti-proliferative, anti-angiogenic and anti-tumor activities.

体外研究

RRD-251 (10-50 μM; 24 hours) inhibits melanoma growth in-vitro.
RRD-251 (50 μM; 2 hours) inhibits Rb-Raf-1 interaction and Rb phosphorylation in non-small cell lung cancer cells.
RRD-251 induces apoptosis (50 μM; 18 hours) and cell cycle arrest (20-50 μM; 4 hours).
RRD-251 alters the expression of cell cycle and apoptosis regulatory protein.

Cell Proliferation Assay

Cell Line:	SK-MEL-28 cells , SK-MEL-5 cells, SK-MEL-2 cells
Concentration:	10 μM, 20 μM, 50 μM
Incubation Time:	24 hours
Result:	Inhibited melanoma growth in-vitro.

Western Blot Analysis

Cell Line:	SK-MEL-28 cells , SK-MEL-5 cells, SK-MEL-2 cells
Concentration:	50 μM
Incubation Time:	2 hours
Result:	Showed the depletion of phosphorylated-Rb in RRD-251 treated cells.

Apoptosis Analysis

Cell Line:	SK-MEL-28 cells , SK-MEL-5 cells, SK-MEL-2 cells
Concentration:	50 μM
Incubation Time:	18 hours
Result:	Induced apoptosis.

Cell Cycle Analysis

Cell Line:	SK-MEL-28 cells , SK-MEL-5 cells
Concentration:	20 μM, 50 μM
Incubation Time:	4 hours
Result:	Resulted in a dose dependent inhibition of cell cycle progression in SK-MEL-28 and SK-MEL-5 cells, respectively.

体内研究

RRD-251 (50 mg/kg; i.p.; q.o.d; for 14 days) has anti-cancer activities in vivo on melanomas.

Animal Model:	8-wk-old female athymic nude mice, with SK-ME-28 xenograft
Dosage:	50 mg/kg
Administration:	Intraperitoneal administration, qod, for 14 days
Result:	Inhibits the growth of SK-ME-28 xenograft in nude mice.

分子式

C₈H₉Cl₃N₂S

分子量

271.59

CAS号

72214-67-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： 98%

Data Sheet

产品使用指南

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