| 生物活性 |
Eplontersen is a triantennary N-acetyl galactosamine (GalNAc3-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases.
|
|---|---|
| 分子量 |
8606.5
|
| CAS号 |
1637600-16-8
|
| 中文名称 |
Eplontersen
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere.
|
| 储存方式 |
-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
|
纯度： 98%
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