| 生物活性 |
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing wild-type EZH2 (Ki: 2.5 nM). It inhibits EZH2 (IC50s: 11 and 16 nM in peptide assay and nucleosome assay).
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 分子式 |
C34H47Cl3N4O4
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| 分子量 |
682.12
|
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| CAS号 |
1403255-00-4
|
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
|
纯度： ≥95%
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