Nivolumab (Synonyms:纳武单抗; BMS-936558; ONO-4538; MDX-1106)
目录号 : KM17001 CAS No. : 946414-94-4 纯度 : 98%

Nivolumab 是一种 PD-1 抗体类抑制剂,用于晚期(转移性)非小细胞肺癌的研究。

规格 价格 是否有货 数量
1mg
In-stock
5mg
In-stock
25mg 询价 In-stock
50mg 询价 In-stock

Other Forms of Rapamycin:

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生物活性

Nivolumab is a programmed death receptor-1 (PD-1) blocking antibody to treat advanced (metastatic) non-small cell lung cancer.

体外研究

Nivolumab binds to CHO cells expressing PD-1 with an EC50 of 1.66 nM, but does not bind to the parental CHO cell line. Nivolumab binds to PD-1 on activated T cells with an EC50 of 0.64 nM. Nivolumab also inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2, with IC50 values of 2.52 and 2.59 nM, respectively. Nivolumab (1.5 ng/mL) can enhance T-cell reactivity in the presence of a T-cell receptor stimulus.

体内研究

Nivolumab (10 and 50 mg/kg, i.v.) is well tolerated in cynomolgus monkeys. Serum chemistry changes are limited to a reversible 28% decrease in T3 at week 13 in females treated with 50 mg/kg. T4 and TSH levels are unchanged. In males treated with 50 mg/kg, there are no changes in T3, T4, or TSH levels. Nivolumab exposure increases in an approximately dose-proportional manner between 10 and 50 mg/kg, with no substantial sex differences noted.

分子量
143599.09
CAS号
946414-94-4
中文名称
纳武单抗;尼鲁单抗
运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

临床试验
科研文献

纯度: 98%

The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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