Prodipine hydrochloride - CAS:31314-39-3

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Prodipine hydrochloride (Synonyms:普罗地平盐酸盐；卜罗哌苯盐酸盐)

目录号 : KM6216 CAS No. : 31314-39-3 纯度 : 97%

Data Sheet 产品使用指南

Prodipine 是一种二苯基膦酸酯衍生物。抑制兔纯化的和血浆中的二肽基肽酶 IV (DPP IV)，IC₅₀ 分别为 4.5 μM 和 30 μM。

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生物活性	Prodipine, a diphenyl-phosphonate derivative. The IC₅₀s of Prodipine for purified and plasma Dipeptidyl peptidase IV (DPP IV) from the rabbit are 4.5 μM and 30 μM, respectively.
体外研究	Prodipine, a diphenyl-phosphonate derivative selected from a group of slow-binding irreversible inhibitors of this enzyme. The IC₅₀ values of Prodipine for purified and plasma DPP IV from the rabbit are 4.5 μM and 30 μM, respectively.
体内研究	Male rabbits weighing 3-4 kg receive a single intravenous injection with 10 mg Prodipine or saline. After 1 hr, plasma DPP IV activity has decreased to less than 20% of the preinjection value and remaines unchanged during a 24 hr observation period. A profound and long-lasting inhibition of plasma DPP IV activity is observed in the treated animals (1, 5 or 10 mg). It takes 5 to 8 days to reach half of the pretreatment DPP IV activity and generally more than 20 days for a complete recovery.
分子式	C₂₀H₂₅N^.HCl
分子量	315.88
CAS号	31314-39-3
中文名称	普罗地平盐酸盐；卜罗哌苯盐酸盐
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)