AMY-101 - CAS:1427001-89-5

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AMY-101 (Synonyms:Cp40)

目录号 : KM18837 CAS No. : 1427001-89-5 纯度 : 98%

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AMY-101 (Cp40) 是补体 C3 的肽类抑制剂 (K_D = 0.5 nM)，可抑制非人类灵长类动物自然发生的牙周炎。AMY-101 (Cp40) 在 COVID-19 重症肺炎合并全身超炎症模型中具有良好的抗炎活性。

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock

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生物活性

AMY-101 (Cp40), a peptidic inhibitor of the central complement component C3 (K_D = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation.

IC₅₀&Target

KD: 0.5 nM (C3).

体内研究

AMY-101 can improve the periodontal condition of NHPs with natural chronic periodontitis.
AMY-101 can induce a long-lasting anti-inflammatory effect.
AMY-101 (4 mg/kg bodyweight, subcutaneous injection. once per 24 hr for a total of 28 days) causes a significant and long-lasting reduction in PPD, an index that measures tissue destruction.
AMY-101 (Cp40, 1 mg/kg, sc, injection every 12 h, daily, 7 or 14 days) attenuates fibrosis and infiltration of inflammatory cells in UUO-induced renal fibrosis.

Animal Model:	Fifteen adult male cynomolgus monkeys (Macaca fascicularis) (7-15 years old; 5.0-7.6 kg body weight).
Dosage:	0.1 mg/site; 50 μL of 2 mg/mL solution.
Administration:	Injected locally. (Either three times per week or once a week for 6 weeks followed by a 6-week follow-up period without treatment.)
Result:	Does not cause irritation in healthy gingiva.

Animal Model:	UUO and sham-operated mice.
Dosage:	1 mg/kg.
Administration:	Subcutaneous injection every 12 h, daily, 7 or 14 days.
Result:	1 mg/kg Cp40 had much less severe interstitial fibrosis than control peptide-injected mice.

分子式

C₈₃H₁₁₇N₂₃O₁₈S₂

分子量

1789.11

CAS号

1427001-89-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

临床试验

科研文献

•Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.

纯度： 98%

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