| 生物活性 |
Dimethylamino parthenolide (DMAPT) is an inhibitor of NF-κB and a derivative of parthenolide . It inhibits the binding of the p65 subunit of NF-κB to DNA by 75% when used at a concentration of 50 µM. DMAPT (25 µM) decreases intracellular glutathione (GSH) levels in, and inhibits the migration of, MDA-MB-231 breast cancer cells. It induces necrosis in MDA-MB-231 cells, an effect that can be reversed by the antioxidant N-acetyl cysteine , NADPH oxidase inhibitor apocynin , or RIP1 kinase inhibitor necrostatin-1 . DMAPT (50 mg/kg) decreases tumor volume in an MDA-MB-231 mouse xenograft model.
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| 分子式 |
C17H27NO3
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| 分子量 |
293.4
|
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| CAS号 |
791595-09-0
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| 中文名称 |
NND-22102404
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
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纯度： >97%
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