Terodiline hydrochloride 是一种 M1 选择性的毒蕈碱受体 (muscarinic receptor; mAChR) 拮抗剂。 对兔输精管 (M1)，心房 (M2)，膀胱 (M3)，回肠肌 (M3) 的 Kb 分别为 15，160，280，和 198 nM。Terodiline hydrochloride 还是钙通道 (Ca2+) 阻断剂。Terodiline hydrochloride 可用于尿频和急迫性尿失禁的研究。
| 生物活性 |
Terodiline hydrochloride is an M1-selective muscarinic receptor (mAChR) antagonist with Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a Ca blocker. Terodiline hydrochloride acts as a treatment for urinary frequency and urge incontinence. |
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| 体内研究 |
Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID50= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED50=59 mg/kg).
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| 分子式 |
C20H27N.HCl
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| 分子量 |
317.90
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| CAS号 |
7082-21-5
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| 中文名称 |
盐酸特罗地林
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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