KKL 顾客使用本产品发表的 2 篇科研文献

KY02111 is a canonical WNT signaling (β-catenin) inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration.

KY02111 promotes differentiation by inhibiting WNT signaling in hPSCs.
KY02111 induces cardiomyocytes expressed the cardiac markers, αMHC, NKH2.5, and HCN4.
KY02111 (1-10 μM; 12 hours, 24 hours) reduces WNT signaling in both IMR90-1 cells and HEK293 cells in a dose-dependent manner.
KY02111 treatment with WNT signaling modulators produces robust cardiac differentiation of hPSCs in a xeno-free, defined medium, devoid of serum and any kind of recombinant cytokines and hormones, such as BMP4, Activin A, or insulin.

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