4-Hydroxyatomoxetine 是Atomoxetine 的活性代谢产物。4-Hydroxyatomoxetine 通过细胞色素 P450 2D6 (CYP2D6) 酶代谢。Atomoxetine 是去甲肾上腺素重吸收抑制剂，与人 NET，SERT 和 DAT 的放射性配体结合的 Ki 分别为 5 nM，77 nM 和 1451 nM。
| 生物活性 |
4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). |
|---|---|
| 分子式 |
C17H21NO2
|
| 分子量 |
271.35
|
| CAS号 |
435293-66-6
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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