PF-06648671 是一种新型的，可通透血脑屏障的，具有口服活性的 γ 分泌酶 (γ‐Secretase) 调节剂 (GSM)。PF-06648671 减少 Aβ42 和 Aβ40，并且伴随 Aβ37 和 Aβ38 的增加。PF-06648671 用于阿尔茨海默病的研究。
| 生物活性 |
PF-06648671 is a novel, brain‐penetrable, and orally active γ‐secretase modulator (GSM). PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimer’s disease. |
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| 体外研究 |
In a cell‐based assay, PF‐06648671 reduces Aβ42 and Aβ40 , with concomitant increases in Aβ37 and Aβ38, without inhibiting the cleavage of Notch or other substrates. |
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| 体内研究 |
PF‐06648671 demonstrates reduces Aβ42 within the brain and CSF following acute oral administration in animals.
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| 分子式 |
C25H23ClF4N4O3
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| 分子量 |
538.92
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| CAS号 |
1587727-31-8
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 临床试验 |
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纯度： 98%
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