SRX3177 是 CDK4/6、PI3K 和 BRD4 的三重抑制剂，IC₅₀ 分别为 33 nM (BRD4 BD1)、89 nM (BRD4 BD2)、79 nM (PI3Kα)、83 nM (PI3Kδ)、3.18 μM (PI3Kγ)、<2.5 nM (CDK4)、3.3 nM (CDK6)。SRX3177 对癌细胞具有广泛的细胞毒活性，但对正常上皮细胞友好。
| 生物活性 |
SRX3177 is a triple inhibitor of CDK4/6, PI3K, and BRD4, with IC₅₀ s of 33 nM (BRD4 BD1), 89 nM (BRD4 BD2), 79 nM (PI3Kα), 83 nM (PI3Kδ), 3.18 μM (PI3Kγ), <2.5 nM (CDK4), 3.3 nM (CDK6), respectively. SRX3177 exerts broad cytotoxic activity against cancer cells, but acts friendly with normal epithelial cells. |
|---|---|
| 分子式 |
C31H32N6O4S
|
| 分子量 |
584.69
|
| CAS号 |
2241237-51-2
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Store at 2-8˚C |
客服小K 
客服小K
Data Sheet
