RA375 - KKL Med Inc.

您当前的位置：

RA375

目录号 : KM8233

Data Sheet 产品使用指南

RA375 是 RPN13 (26S 蛋白酶体亚基) 抑制剂。RA375 激活 UPR 信号、ROS 产生和凋亡。RA375 的抗肿瘤活性是 RA190的 10 倍。

规格	价格	是否有货	数量
5mg		In-stock
10mg		In-stock
50mg		In-stock
100mg		In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

(Tyr0)-Urocortin, rat In-stock
Stressin I In-stock
Suc-AAA-pNA In-stock
Perfluoropolyether carboxylic acid In-stock
Ala-D-γ-Glu-Lys-D-Ala-D-Ala In-stock

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead.

体内研究

RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice.

Animal Model:	RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice.
Dosage:	10 mg/kg.
Administration:	IP for a 5 days on, 2 days off cycle for two weeks.
Result:	Reduced ovarian tumor burden in mice.

Animal Model:	Female Balb/c mice.
Dosage:	5, 10, 20, 40, 60, 100 mg/kg (Pharmacological Analysis).
Administration:	IP single dose.
Result:	The dose of 40 mg/kg on alternate days for two weeks produced no observable toxicities or weight loss.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据

In Vitro:

DMSO : 125 mg/mL (212.22 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6978 mL	8.4890 mL	16.9779 mL
5 mM	0.3396 mL	1.6978 mL	3.3956 mL
10 mM	0.1698 mL	0.8489 mL	1.6978 mL

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

联系我们

400-881-9290
technical-service@kklmed.com

terminal-order@kklmed.com

terminal-inspection@kklmed.com

dealer-order@kklmed.com
10338 stony run ln，ste121，ashland，va，23005，USA

客户服务

快速询价订购信息售后服务退货和退款销售通用条款 Literature Award

KKL MED 小分子

KKL MED

关注我们

获得KKL MED 最新资讯

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 0 篇科研文献

The molarity calculator equation

The dilution calculator equation