RO0270608，是 R411 的活性代谢物，是一种双重 alpha4beta1-alpha4beta7 (α4β1/α4β7) 整合素拮抗剂。具有抗炎活性。
| 生物活性 |
RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. Antiinflammatory activity. |
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| 体外研究 |
RO0270608 inhibits α4/β7 mediated cell adhesion with an IC50 of 33 nM. In a human T-cell VCAM/anti CD3 costimulation assay RO0270608 causes a pronounced inhibition of T-cell proliferation (IC50=30 nM). |
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| 体内研究 |
In a murine OVA-model of airway inflammation, RO0270608 i.n. abolishes allergen-induced inflammatory cell accumulation
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| 分子式 |
C24H19N2O4Cl3
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| 分子量 |
505.78
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| CAS号 |
220846-33-3
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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Data Sheet
