KKL 顾客使用本产品发表的 1 篇科研文献

Vipadenant (BIIB-014; CEB-4520) is an adenosine receptor antagonist, with K_is of 1.3 nM and 68 nM for A_2A and A₁, respectively.

Vipadenant (0.3-30 mg/kg) produces a dose-dependent reduction in catalepsy. Vipadenant (10 mg/kg) does not produce any statistically significant dyskinetic episodes in 6-OHDA-lesioned rats during a 19-day dosing regimen. In the mouse and rat haloperidol-induced hypolocomotion models, vipadenant has a minimum effective dose of 0.1 and 1 mg/kg, respectively. Vipadenant (3 and 10 mg/kg, p.o.) is able to increase contralateral rotations in 6-OHDA lesioned rats.

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