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NF-κΒ activator 2 is a potent and orally active NF-ҡB activator, with an EC₅₀ of 1.58 μM. NF-κΒ activator 2 induces SOD₂ through increasing NF-ҡB expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS).

NF-κΒ activator 2 (compound 61) (1 μM, 6 h) induces SOD₂ mRNA expression in SH-SY5Y neuroblastoma cells.

NF-κΒ activator 2 (1 mg/kg; i.v.) displays a suitable half-life (0.96 h) in mice.
NF-κΒ activator 2 (5 mg/kg; p.o.) displays a comparable half-life (2.86 h), oral bioavailability (15.6%), and C_max (92 ng/mL).

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