NS 383
目录号 : KG12797
CAS No. : 309711-59-9
纯度 : 98%
ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.
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分子式 |
C19H19N3O2
|
分子量 |
321.37
|
CAS号 |
309711-59-9
|
中文名称 |
NS 383
|
储存方式 |
Store at -20°C
|