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PSI-697 (Synonyms:P-Selectin Inhibitor)
目录号 : KM6636 CAS No. : 851546-61-7 纯度 : 98%

PSI-697 是一种口服的 P-selectin 抑制剂,IC50 值为 125 μM。

规格 价格 是否有货 数量
1mg
In-stock
5mg
In-stock
10mg
In-stock
50mg
In-stock
100mg
In-stock
200mg 询价 In-stock
500mg 询价 In-stock

Other Forms of Rapamycin:

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生物活性

PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM.

体外研究

PSI-697 inhibits the binding of a soluble human P-selectin to PSGL-1, in a reproducible concentration-dependent manner inhibiting 50% of binding at a concentration of 125 μM in vitro.

体内研究

PSI-697 (0-50 mg/kg; p.o.) significantly reduces the number of rolling leukocytes by 39% versus vehicle control.
PSI-697 (100 mg/kg; p.o.) reduces thrombus weight by 18% relative to vehicle, without prolonging bleeding time in a rat venous thrombosis model.
PSI-697 (30 mg/kg; p.o.; daily; 6 days) promotes thrombus resolution and decreases inflammation in a baboon model of venous thrombosis.
PSI-697 ((30 mg/kg; i.g.; daily) decreases vein wall injury in a rat stenosis model of venous thrombosis.

Animal Model: 4-5 weeks male Sprague-Dawley rat (50-100 g)
Dosage: 0 mg/kg, 30 mg/kg, 50 mg/kg
Administration: Oral administration
Result: At an oral dose of 50 mg/kg reduced the number of rolling leukocytes by 39% versus vehicle control.
分子式
C21H18ClNO3
分子量
367.83
CAS号
851546-61-7
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 45.8 mg/mL (124.51 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7186 mL 13.5932 mL 27.1865 mL
5 mM 0.5437 mL 2.7186 mL 5.4373 mL
10 mM 0.2719 mL 1.3593 mL 2.7186 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

临床试验
科研文献
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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