UK122 是一种有效的，选择性尿激酶型纤溶酶原激活剂 (uPA) 抑制剂，IC50 为 0.2 μM。UK122 对组织型 PA (tPA)、纤溶酶、凝血酶和胰蛋白酶没有或几乎没有抑制作用(IC50>100 μM)。UK122 是 4-恶唑烷酮类似物，一种抗癌剂，可抑制癌细胞迁移和侵袭。
| 生物活性 |
UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion. |
|---|---|
| 体外研究 |
UK122 (11.1, 33.3, 100 μM; 24 h) dose-dependently inhibits cell migration and significantly reduces the invasiveness of CFPAC-1 cells. |
| 分子式 |
C17H13N3O2
|
| 分子量 |
291.30
|
| CAS号 |
940290-58-4
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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