KKL 顾客使用本产品发表的 3 篇科研文献

cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.

cGAMP disodium promotes the antigen-specific proliferation capacity of spleen cells in mice.
cGAMP disodium directly activates murine and human dendritic cells in vitro.
On stimulation with cGAMP disodium, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF).
cGAMP disodium activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs.

cGAMP (5 µg; nostril mucosal adjuvant) disodium promotes the antigen-specific cytokine production by spleen cells of immunized mice.

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