8-Cyclopentyl-1,3-dimethylxanthine
(Synonyms:8-环戊- 1 ,3 -二甲基黄嘌呤;8-环戊基-1,3-二甲基黄嘌呤;A1受体拮抗剂,CPT)
目录号 : KCM13513
CAS No. : 35873-49-5
纯度 : ≥98%
8-Cyclopentyl-1,3-dimethylxanthine (CPT) is an adenosine A receptor antagonist (K = 10.9 nM). It is selective for adenosine A over A receptors (K = 1,440 nM). CPT inhibits hypoxia-induced depression of evoked synaptic potentials in rat hippocampal slices in a concentration-dependent manner. It increases secondary after-discharge duration in electrically induced seizures in rats when administered at doses of 2.5 mg/kg or higher. CPT increases the response rate under a fixed-interval schedule of stimulus-shock termination in squirrel monkeys (ED = 2.5 μmol/kg), indicating psychomotor stimulant effects.
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分子式 |
C12H16N4O2
|
分子量 |
248.2812
|
CAS号 |
35873-49-5
|
中文名称 |
A1受体拮抗剂,CPT
|
储存方式 |
-20°C
|