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GRI-977143 (Synonyms:1,4-二氧杂螺[4.5]癸烷-8-硼酸频哪醇酯;2-[3-(1,3-二氧代-1H,3H-苯并[de]异喹啉-2-基)-丙基磺酰基]-苯甲酸)
目录号 : KCM13311 CAS No. : 325850-81-5 纯度 : ≥98%
Data Sheet SDS 产品使用指南
GRI-977143 is an agonist of G protein-coupled lysophosphatidic acid receptor 2 (LPA) with an EC value of 3.3 μM in LPA-transfected RH7777 cells. It is selective for LPA, having no activity at LPA, LPA, LPA, and LPA at concentrations up to 10 μM. GRI-977143 increases growth and reduces caspase-3 and -7 activation in LPA-transduced MEF fibroblasts. It increases MM1 rat hepatoma cell invasion and inhibits apoptosis of IEC-6 cells induced by TNF-α, doxorubicin , or serum withdrawal. GRI-977143 also rescues apoptotic cells from γ-irradiation-induced injury in vitro and in vivo.
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分子式
C22H17NO4S
分子量
391.4
CAS号
325850-81-5
中文名称
2-[3-(1,3-二氧代-1H,3H-苯并[de]异喹啉-2-基)-丙基磺酰基]-苯甲酸
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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