VUF 5574
目录号 : KCM13117
CAS No. : 280570-45-8
纯度 : ≥98%
VUF 5574 is an antagonist of the adenosine A receptor (K = 4.03 nM for the recombinant human receptor). It is greater than 2,500-fold selective for adenosine A over A and A receptors. VUF 5574 (100 nM) decreases phosphorylation of ERK1/2 induced by adenosine in isolated porcine coronary artery smooth muscle cells. It increases oxygen-glucose deprivation-induced reductions in the amplitude of field excitatory postsynaptic potentials (EPSPs) in a rat hippocampal slice model of ischemia when used at a concentration of 100 nM. VUF 5574 (2 µg, intracisternal) reduces sodium nitroprusside-induced heart rate increases in rats.
Other Forms of Rapamycin:
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分子式 |
C21H17N5O2
|
分子量 |
371.39218
|
CAS号 |
280570-45-8
|
储存方式 |
-20°C
|