Tin-protoporphyrin IX - CAS:14325-05-4

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Tin-protoporphyrin IX (Synonyms:锡原卟啉IX; SnPPIX; Stannous protoporphyrin IX)

目录号 : KM5744 CAS No. : 14325-05-4 纯度 : ≥95%

Data Sheet 产品使用指南

Tin-protoporphyrin IX (SnPPIX) 是有效的血红素加氧酶-1 (HO-1) 抑制剂。 Tin-protoporphyrin IX (SnPPIX) 使 PDAC 管腺癌肿瘤对化疗敏感。

规格	价格	是否有货	数量
5mg		In-stock
10mg		In-stock
50mg		In-stock

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生物活性

Tin-protoporphyrin IX (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model.

体外研究

Tin-protoporphyrin IX (SnPPIX)(20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, SnPPIX has no significant effect on PDAC cells proliferation at all exposures except at 50 μM.

Cell Viability Assay

Cell Line:	Capan-1, CD18/HPAF, PDAC cells
Concentration:	20 μM, 50 μM
Incubation Time:	24 or 72 hours
Result:	Inhibited Capan-1 and CD18/HPAF cells proliferation and inhibits PDAC cells growth at 50μM.

体内研究

Tin-protoporphyrin IX (SnPPIX)(intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment.

Animal Model:	Male and female athymic nude mice with PDAC cell-derived xenograft tumors
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20
Result:	Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine).

分子式

C₃₄H₃₂N₄O₄Sn

分子量

750.26

CAS号

14325-05-4

中文名称

锡原卟啉IX

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

0.1 M NaOH : 14.29 mg/mL (19.05 mM; ultrasonic and adjust pH to 12 with NaOH)

DMF : 1 mg/mL (1.33 mM; Need ultrasonic and warming)

DMSO : 0.5 mg/mL (0.67 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.3329 mL	6.6644 mL	13.3287 mL
5 mM	0.2666 mL	1.3329 mL	2.6657 mL
10 mM	0.1333 mL	0.6664 mL	1.3329 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

科研文献

纯度： ≥95%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

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Other Forms of Rapamycin:

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The molarity calculator equation

The dilution calculator equation