Zinc Protoporphyrin - CAS:15442-64-5

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Zinc Protoporphyrin (Synonyms:锌原卟啉; Zn(II)-protoporphyrin IX; ZnPP; Zinc Protoporphyrin-9)

目录号 : KM5743 CAS No. : 15442-64-5 纯度 : ≥98%

Data Sheet 产品使用指南

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) 是一种具有口服活性的，竞争性的血红素加氧酶-1 (HO-1) 抑制剂，显着减弱间苯三酚 (PG) 对 H₂O₂ 的保护作用。Zinc Protoporphyrin 可用作个体孕妇和儿童缺铁的筛查标志物，也用于评估人群铁状态与血红蛋白浓度的组合。Zinc Protoporphyrin 具有抗癌活性。

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock

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生物活性

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H₂O₂. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration. Zinc Protoporphyrin has anti-cancer activity.

体外研究

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX; 5 μM; 72 hours) causes the fraction of late apoptotic and necrotic cells increasing from 10.9% in controls to 30.4% after 72 h.
Zinc Protoporphyrin (1.25-40 μM; 48 or 72 hours) exerts cystostatic/cytotoxic effects against tumor cells.
Zinc Protoporphyrin (2.5, 5 μM; 48 or 72 hours) results in dose- and time-dependent reduction of cells in G1 phase of the cell cycle.
Zinc Protoporphyrin (1.25-40 μM; 48 hours) leads to accumulation of cleaved (active) caspase-3.

Apoptosis Analysis

Cell Line:	C-26 cells
Concentration:	5 μM
Incubation Time:	72 hours
Result:	The fraction of late apoptotic and necrotic cells increased from 10.9% in controls to 30.4% after 72 h.

Cell Cytotoxicity Assay

Cell Line:	C-26 and MDA-MB231 cells
Concentration:	1.25, 2.5, 5, 10, 20, 40 μM
Incubation Time:	48 or 72 hours
Result:	Exerted cystostatic/cytotoxic effects against tumor cells.

Cell Cycle Analysis

Cell Line:	C-26 cells
Concentration:	2.5, 5 μM
Incubation Time:	48 or 72 hours
Result:	Resulted in dose- and time-dependent reduction of cells in G1 phase of the cell cycle.

Western Blot Analysis

Cell Line:	C-26 cells
Concentration:	1.25, 2.5, 5, 10, 20, 40 μM
Incubation Time:	48 hours
Result:	Leaded to accumulation of cleaved (active) caspase-3.

体内研究

Zinc Protoporphyrin (12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.; from day 7 to 19) exerts dose-dependent antitumor effects manifested by the retardation of tumor growth.

Animal Model:	BALB/c mice inoculated with C-26 cells
Dosage:	12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.
Administration:	IP or PO; from day 7 to 19
Result:	Exerted dose-dependent antitumor effects manifested by the retardation of tumor growth.

分子式

C₃₄H₃₂N₄O₄Zn

分子量

626.02

CAS号

15442-64-5

中文名称

锌原卟啉

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 20.83 mg/mL (33.27 mM; ultrasonic and warming and heat to 80°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5974 mL	7.9870 mL	15.9739 mL
5 mM	0.3195 mL	1.5974 mL	3.1948 mL
10 mM	0.1597 mL	0.7987 mL	1.5974 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 50% PEG300→50% saline

Solubility: 1.67 mg/mL (2.67 mM); Suspended solution; Need ultrasonic

科研文献

纯度： ≥98%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

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Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 6 篇科研文献

The molarity calculator equation

The dilution calculator equation