Garenoxacin
(Synonyms:加雷沙星;1-环丙基-8-(二氟甲氧基)-7-[(1R)-1-甲基-2,3-二氢-1H-异吲哚-5-基]-4-氧代喹啉-3-羧酸;加雷沙星杂质)
目录号 : KCM12298
CAS No. : 194804-75-6
纯度 : ≥98%
Garenoxacin is a quinolone antibiotic. It is active against a variety of Gram-positive and Gram-negative bacteria (MICs = 0.025-6.25 and 0.0125-100 µg/ml, respectively). Garenoxacin inhibits E. coli DNA gyrase supercoiling and S. aureus topoisomerase IV decatenation activities (ICs = 0.17 and 2.19 mg/L, respectively). It is selective for S. aureus topoisomerase IV over human topoisomerase II (IC = 509.7 µg/L). Garenoxacin is efficacious against systemic quinolone-resistant S. aureus infection and pneumonia induced by the penicillin-resistant S. pneumoniae clinical isolate D-979 in mice (EDs = 0.0189 and 0.0278 mg/animal, respectively).
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分子式 |
C23H20F2N2O4
|
分子量 |
426.4127864
|
CAS号 |
194804-75-6
|
中文名称 |
加雷沙星
|
储存方式 |
-20°C
|