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LB-100
目录号 : KCM11837 CAS No. : 1632032-53-1 纯度 : ≥98%
Data Sheet 产品使用指南
LB-100 is an inhibitor of protein phosphatase 2A (PP2A) with anticancer activity. It reduces PP2A activity and is cytotoxic to BxPC-3 and PANC-1 cells (ICs = 0.85 and 3.87 μM, respectively). LB-100 inhibits radiation-induced Rad51 focus formation and homologous recombination repair in PANC-1 and MiaPaCa-2 cells. In vivo, it increases tumor microvessel density and VEGF secretion and decreases tumor volume in a PANC-1 mouse xenograft model when administered at a dose of 2 mg/kg. LB-100 (1.5 mg/kg) enhances radiation-induced reductions in tumor volume in CNE1 and CNE2 radioresistant nasopharyngeal carcinoma mouse xenograft models.
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分子式
C13H20N2O4
分子量
268.30898
CAS号
1632032-53-1
中文名称
1632032-53-1
储存方式
-20°C
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