GSK199 (hydrochloride) - CAS:1549811-53-1

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GSK199 (hydrochloride)

目录号 : KCM11659 CAS No. : 1549811-53-1 纯度 : ≥98%

Data Sheet 产品使用指南

Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases. GSK199 is a reversible inhibitor of PAD4 (IC = 200 nM) that binds to the low-calcium form of the enzyme and is selective for PAD4 over PAD1-3.It is less potent than the related PAD4 inhibitor GSK484 , which demonstrates an IC value of 50 nM. GSK199 can inhibit the citrullination of PAD4 target proteins and diminish the formation of neutrophil extracellular traps in mouse neutrophils.

规格	价格	是否有货	数量
500μg		In-stock
1mg		In-stock
5mg		In-stock
10mg		In-stock

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分子式	C₂₄H₂₈N₆O₂^.HCl
分子量	432.54
CAS号	1549811-53-1
中文名称	[(3R)-3-amino-1-piperidinyl][2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone,monohydrochloride
储存方式	-20°C