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LDN-193189 (hydrochloride)
目录号 : KCM11414 CAS No. : 1435934-00-1 纯度 : ≥98%
Data Sheet 产品使用指南
LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (ICs = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (ICs = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.
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分子式
C25H22N6.2HCl
分子量
406.48262
CAS号
1435934-00-1
中文名称
LDN 193189 hydrochloride
储存方式
-20°C
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