LM11A-31 dihydrochloride - CAS:1243259-19-9

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LM11A-31 dihydrochloride

目录号 : KM5542 CAS No. : 1243259-19-9 纯度 : ≥98%

Data Sheet 产品使用指南

LM11A-31 dihydrochloride 是一种 p75^NTR (神经营养蛋白受体 p75) 非肽调节剂，是口服有效的 proNGF 拮抗剂。LM11A-31 dihydrochloride 是一种具有高血脑屏障通透性的氨基酸衍生物，能阻断 p75 介导的细胞死亡。LM11A-31 dihydrochloride 可以逆转中晚期的阿尔茨海默氏病小鼠模型中的胆碱能神经突营养不良。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

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生物活性

LM11A-31 dihydrochloride, a non-peptide p75 (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 dihydrochloride is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. M11A-31 dihydrochloride reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.

体内研究

LM11A-31 (oral gavage; 50 mg kg/day for 4 weeks) significantly mitigates proNGF accumulation and preserves BRB integrity.
LM11A-31 (orally; 50 or 75 mg/kg) administered for 3 months starting at 6-8 months of age prevents and/or reverses atrophy of basal forebrain cholinergic neurites and cortical dystrophic neurites in mid-stage male APPL/S mice.

Animal Model:	Male C57BL/6 J mice
Dosage:	50 mg kg/day
Administration:	Oral gavage; for 4 weeks
Result:	Mitigated proNGF accumulation and preserved BRB integrity.

分子式

C₁₂H₂₅N₃O₂

分子量

316.27

CAS号

1243259-19-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

溶解性数据

In Vitro:

H₂O : 125 mg/mL (395.23 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1619 mL	15.8093 mL	31.6186 mL
5 mM	0.6324 mL	3.1619 mL	6.3237 mL
10 mM	0.3162 mL	1.5809 mL	3.1619 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

科研文献