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B-RAF Inhibitor 1 (hydrochloride) (Synonyms:N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶]-1,5-异喹啉二胺双盐酸盐)
目录号 : KCM10572 CAS No. : 1191385-19-9 纯度 : ≥98%
Data Sheet SDS 产品使用指南
B-RAF inhibitor 1 is an inhibitor of Raf kinases (Ks = 0.3, 1, and 1 nM for C-RAF, B-RAF, and B-RAF, respectively). It is selective for the B-RAF kinase domain over Lck, Tie2, KDR, and p38α (ICs = 83, 120, 1,000, and >1,600 nM, respectively). B-RAF inhibitor 1 inhibits phosphorylation of ERK in A375 melanoma cells (IC = 1.8 nM). It reduces tumor growth in an A375 SQ2 mouse xenograft model (ED = 1.3 mg/kg per day) and induces 85% tumor regression when administered at a dose of 5 mg/kg per day for 14 days. B-RAF inhibitor 1 (5 and 10 mg/kg per day) increases tumor growth in a MIA PaCa-2 mouse xenograft model.
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分子式
C26H19ClN8.2HCl
分子量
478.93568
CAS号
1191385-19-9
中文名称
N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶]-1,5-异喹啉二胺双盐酸盐
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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